Absolutely. Just use a microfiber cloth (so the little fibers in say a paper towel don’t get stuck on the edges of the letters) and a gentle cleansing solution. Wipe gently (you don’t want to tear the decal off the wall). I’ve had a Wall Quotes™ decal on our bathroom mirror for more than five years now. I clean the mirror regularly with glass cleaner and yes, a paper towel. Every so often fibers stick to the edges, but I wipe them away with a microfiber cloth and it’s good to go. Sparkling mirror, wall decal intact. Same holds true when I wash the walls (which, let’s admit it, is fairly rare though the odd crayon incident has inspired a thorough cleaning every now and again).